Mukesh is an epithet for the Hindu god Shiva, and literally means "conqueror of the Muka demon". It is commonly used as a male given name in India. People with the name Mukesh include:
- Mukesh (singer) (1923–1976), an Indian playback singer
- Mukesh (actor) (born 1961), Indian film actor and producer
- Mukesh Ambani (born 1957), chairman and managing director of Reliance Industries Limited
- Mukesh Batra (born 1951), homeopathy practitioner
- Mukesh Bhatt (born 1952), Indian film producer
- Mukesh Chatter, information technology entrepreneur
- Mukesh Desai, Indian cricketer who played for Gujarat
- Mukesh Goud, Indian politician belonging to the Indian National Congress
- Mukesh Haikerwal (born 1960), general practitioner and former federal president of the Australian Medical Association
- Mukesh Jagtiani, Dubai-based Indian businessman, Chairman Landmark International Group
- Mukesh Kapila, British civil servant and United Nations official
- Mukesh Khanna, Indian television and film actor
- Mukesh Kumar (field hockey) (born 1970), Indian field hockey player
- Mukesh Kumar (golfer) (born 1965), Indian golfer
- Mukesh Patel (1953–2009), Indian entrepreneur
- Mukesh Rishi, Indian film actor
- Mukesh Tiwari, Indian actor
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