Mukesh is an epithet for the Hindu god Shiva, and literally means "conqueror of the Muka demon". It is commonly used as a male given name in India. People with the name Mukesh include:

  • Mukesh (singer) (1923–1976), an Indian playback singer
  • Mukesh (actor) (born 1961), Indian film actor and producer
  • Mukesh Ambani (born 1957), chairman and managing director of Reliance Industries Limited
  • Mukesh Batra (born 1951), homeopathy practitioner
  • Mukesh Bhatt (born 1952), Indian film producer
  • Mukesh Chatter, information technology entrepreneur
  • Mukesh Desai, Indian cricketer who played for Gujarat
  • Mukesh Goud, Indian politician belonging to the Indian National Congress
  • Mukesh Haikerwal (born 1960), general practitioner and former federal president of the Australian Medical Association
  • Mukesh Jagtiani, Dubai-based Indian businessman, Chairman Landmark International Group
  • Mukesh Kapila, British civil servant and United Nations official
  • Mukesh Khanna, Indian television and film actor
  • Mukesh Kumar (field hockey) (born 1970), Indian field hockey player
  • Mukesh Kumar (golfer) (born 1965), Indian golfer
  • Mukesh Patel (1953–2009), Indian entrepreneur
  • Mukesh Rishi, Indian film actor
  • Mukesh Tiwari, Indian actor