Holtz is the surname of:
- Andrew Holtz, American journalist
- Brian Holtz (born 1965), American politician, writer and software engineer
- Carl Holtz (1920-2006), American oarsman and farmer
- Daniel Holtz, a fictional character on the TV series Angel
- Franz Holtz, Canadian traveler
- Jürgen Holtz, German actor
- Hyman Holtz (1896- c. 1939), American mobster
- Kaila Holtz (born 1981), a 2004 Canadian Olympic softball pitcher
- Lou Holtz (1893-1980), American comedian
- Lou L. Holtz (born 1937), a retired national championship winning college football coach
- Marianne Holtz, German singer and comedian
- Mark Holtz (1945-1997), former broadcaster for the Texas Rangers
- Mike Holtz (born 1972), American baseball player
- Pat Holtz, Scottish pool player
- Skip Holtz (born 1964), head football coach of University of South Florida
- Stefan Holtz (born 1981), German canoer
- Tenen Holtz (1877-1971), Russian actor
- Thomas R. Holtz, Jr., palaeontologist and senior lecturer in geology at University of Maryland, USA
- Uwe Holtz, German political scientist
- Viktor Holtz (1846-1919), a German educator and a pioneer of German-Japanese academic and cultural relations.
- Wilhelm Holtz (1836-1913), German physicist and inventor of the Holtz machine