Zaimis (Greek: Ζαΐμης) is the surname of two Prime Ministers of Greece and others:
- Alexandros Zaimis, Prime Minister of Greece five times in the late 1890s and the early-20th century
- Androutsos Zaimis, took part in 1751 against the Turks
- Andreas Zaimis (1791–1840), a Greek minister and soldier in the Greek War of Independence
- Andreas Zaimis (younger), Achaia politician
- Asimakos Zaimis, a politician
- Dimitrios Zaimis, revolutionary leader
- Filippos Zaimis, chief of Kalavryta
- Fokion Zaimis, politician
- Ioannis Zaimis (1797–1882), first Mayor of Patras
- Konstantinos Zaimis, politician
- Panagiotis Zaimis
- Theodoros Zaimis, politician and doctor
- Thrasivoulos Zaimis (1822–1880), Prime Minister of Greece several times in the 1870s