OFC may refer to:

  • Corporate Office Properties Trust (ticker symbol)
  • Oceania Football Confederation
  • Offshore Financial Centre
  • Online Film Critics Society
  • Open fiber control
  • Open Financial Connectivity, a financial transition file format
  • Optical fiber cable
  • Optical Fiber Conference
  • Optional federal charter, a proposal to streamline and simplify US insurance regulation
  • Orbitofrontal cortex, a region of the brain involved in decision making and other cognitive functions
  • Orpington F.C., an English non-league football club
  • Osteitis fibrosa cystica, a skeletal disease involving the parathyroid glands
  • Ottawa Folklore Centre
  • Oxygen-free copper, a copper cable manufacturing process
  • ofc, an SMS language abbreviation for "of course"
  • Oxy-fuel cutting, a metal cutting process