OFC may refer to:
- Corporate Office Properties Trust (ticker symbol)
- Oceania Football Confederation
- Offshore Financial Centre
- Online Film Critics Society
- Open fiber control
- Open Financial Connectivity, a financial transition file format
- Optical fiber cable
- Optical Fiber Conference
- Optional federal charter, a proposal to streamline and simplify US insurance regulation
- Orbitofrontal cortex, a region of the brain involved in decision making and other cognitive functions
- Orpington F.C., an English non-league football club
- Osteitis fibrosa cystica, a skeletal disease involving the parathyroid glands
- Ottawa Folklore Centre
- Oxygen-free copper, a copper cable manufacturing process
- ofc, an SMS language abbreviation for "of course"
- Oxy-fuel cutting, a metal cutting process