FBS can refer to:
- Federal Bureau of Statistics, the Statistics Division of the Government of Pakistan
- Fetal bovine serum
- Fatboy Slim, a British DJ, musician, and producer
- The postnominal letters indicating fellowship of The Burgon Society, a research based award.
- Fasting blood sugar, a laboratory test used to determine the level of glucose in the blood
- Frozen brain syndrome, another term for ice-cream headache
- Football Bowl Subdivision, formerly known as Division I-A, an American football classification for NCAA collegiate football
- Friern Barnet Secondary School, Barnet, UK
- Fukuoka Broadcasting Corporation, a TV station in Japan, referred as FBS, acronym of Fukuoka Broadcasting System
- Furness Building Society, Barrow-in-Furness, UK
- Full Body Spinner, a combat robot weapon design
- Friendship books, a form of mail art
- Frontiers in Bioscience, academic journal
- Ramallah Friends Schools, friends Boys School
- Foreign body sensation
- Fellow of the Burgon Society