RDE can stand for
- Rapidly developing economy, an emerging market that is undergoing rapid growth
- Redundant Data Elimination, the process of reducing file storage requirements through data deduplication
- Revue d'Égyptologie, a scholarly journal of Egyptology (commonly abbreviated RdE)
- Rotating disk electrode, a type of electrode used in electrochemistry
- Route Decision Engine, a component of OpenBGPD
- Rule-developing experimentation, a term used in market research