Simulating Wound Healing From A Growth Perspective
Considerable effort has been devoted to understanding the physical relationships governing wound healing and subsequent scarring, with mathematical models and simulations developed to elucidate these relationships. The growth of tissue around the wound site is a result of the migration of cells and collagen deposition by these cells. The alignment of collagen describes the degree of scarring; basket-weave orientation of collagen is characteristic of normal skin, whereas aligned collagen fibers lead to significant scarring. It has been shown that the growth of tissue and extent of scar formation can be controlled by modulating the stress at a wound site.
The growth of tissue can be simulated using the aforementioned relationships from a biochemical and biomechanical point of view. The biologically active chemicals that play an important role in wound healing are modeled with Fickian diffusion to generate concentration profiles. The balance equation for open systems when modeling wound healing incorporates mass growth due to cell migration and proliferation. Here the following equation is used:
Dtρ0 = Div (R) + R0,
where ρ represents mass density, R represents a mass flux (from cell migration), and R0 represents a mass source (from cell proliferation, division, or enlargement).
Read more about this topic: Wound Healing
Famous quotes containing the words simulating, wound, healing, growth and/or perspective:
“Would it be possible to stand still on one spot more majestically—while simulating a triumphant march forward—than it is done by the two English Houses of Parliament?”
—Alexander Herzen (1812–1870)
“We cannot assume the injustice of any actions which only create offense, and especially as regards religion and morals. He who utters or does anything to wound the conscience and moral sense of others, may indeed act immorally; but, so long as he is not guilty of being importunate, he violates no right.”
—Karl Wilhelm Von Humboldt (1767–1835)
“When pain of the world surrounds us with darkness and despair,
When searching just confounds us with false hopes ev’rywhere,
When lives are starved for meaning and destiny is bare,
We are called to follow Jesus and let God’s healing flow through us.”
—Jim Strathdee (20th century)
“All growth is a leap in the dark, a spontaneous unpremeditated act without benefit of experience.”
—Henry Miller (1891–1980)
“The fact that illness is associated with the poor—who are, from the perspective of the privileged, aliens in one’s midst—reinforces the association of illness with the foreign: with an exotic, often primitive place.”
—Susan Sontag (b. 1933)