Related To Other Diseases
Witzelsucht can occur in the context of frontotemporal dementia, a neurological disorder resulting from degeneration of the frontal lobes and/or anterior temporal lobes. There are a range of neuropsychiatric symptoms associated with frontal lobe dementia, including progressive declines in social conduct, insight, and personal and emotional regulation and reactivity. The most common social changes that arise in patients include awkwardness, decreased propriety and manners, unacceptable physical boundaries, and/or improper verbal or physical acts. Childish, frivolous, or silly behavior is associated with damage to the right frontal, and most likely adjacent orbitofrontal lobe involvement. This can be associated with witzelsucht, as well as moria- a similar disorder resulting in childish euphoria and cheerful excitement.
Witzelsucht is considered a disorder of mirth or humor, which is distinct from disorders of laughter. Patients with witzelsucht are essentially insensitive to humor, but are capable of producing it while other patients excessively laugh, often at things that are not funny. The most common disorders of laughter are associated with pseudobulbar palsy, which can be caused by severe brain trauma, most commonly in the right hemisphere. Pathological laughter in this can be triggered by trivial stimuli, which could be disconnected from the underlying mood, and be combined with crying. Pathological laughter can also occur in the absence of psudobulbar palsy. Gelastic (laughing) seizures are another neurological case of inappropriate or excessive laughter occurring in brief bursts. Treatment for these disorders can include antidepressants and antimanic agents.
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