PFA may stand for:
- Pacific Film Archive
- Paraformaldehyde
- Perfluoroalkoxy plastic or polymer resin
- Perifornical Area the Hypothalamus, a part of the brain
- The Planet's Funniest Animals
- Police Federation of Australia
- Policía Federal Argentina: Argentine Federal Police
- Popular Flying Association
- Popular Front of Azerbaijan
- .pfa is 'Printer Font ASCII' - a file extension for a Postscript font
- Predictive failure analysis, a technology for hard disk health monitoring, the predecessor of S.M.A.R.T.
- Prime Factor Algorithm, a fast algorithm for computing the Discrete Fourier transform
- Professional Footballers' Association
- Professional Footballers Australia
- Professional Fraternity Association
- Program Field Address, see Forth programming language
- Pulverised fuel ash
- Protection From Abuse
- Proper forcing axiom