Natchez may refer to:
- Natchez people, a Native American nation
- Natchez language, the language of that Native American tribe
- Natchez, Mississippi, United States
- Natchez, Louisiana, United States
- Natchez, Indiana, United States
- Natchez (horse), American rachorse
- Natchez (boat), several vessels of the same name
- USS Natchez, three U.S. Navy ships of the same name
- Les Natchez, a novel by French author François-René de Chateaubriand
- The Natchez, a painting by Eugène Delacroix