Examples
For a more comprehensive list, see List of monoclonal antibodies. List of FDA approved therapeutic antibodies is found in Monoclonal antibody therapyBelow are examples of clinically important monoclonal antibodies.
| Main category | Type | Application | Mechanism/Target | Mode |
|---|---|---|---|---|
| Anti- inflammatory |
infliximab |
|
inhibits TNF-α | chimeric |
| adalimumab |
|
inhibits TNF-α | human | |
| basiliximab |
|
inhibits IL-2 on activated T cells | chimeric | |
| daclizumab |
|
inhibits IL-2 on activated T cells | humanized | |
| omalizumab |
|
inhibits human immunoglobulin E (IgE) | humanized | |
| Anti-cancer | gemtuzumab |
|
targets myeloid cell surface antigen CD33 on leukemia cells | humanized |
| alemtuzumab |
|
targets an antigen CD52 on T- and B-lymphocytes | humanized | |
| rituximab |
|
targets phosphoprotein CD20 on B lymphocytes | chimeric | |
| trastuzumab |
|
targets the HER2/neu (erbB2) receptor | humanized | |
| nimotuzumab |
|
EGFR inhibitor | Humanized | |
| cetuximab |
|
EGFR inhibitor | Chimeric | |
| bevacizumab |
|
inhibits VEGF | humanized | |
| Other | palivizumab |
|
inhibits an RSV fusion (F) protein | humanized |
| abciximab |
|
inhibits the receptor GpIIb/IIIa on platelets | chimeric |
Read more about this topic: Monoclonal Antibodies
Famous quotes containing the word examples:
“Histories are more full of examples of the fidelity of dogs than of friends.”
—Alexander Pope (1688–1744)
“In the examples that I here bring in of what I have [read], heard, done or said, I have refrained from daring to alter even the smallest and most indifferent circumstances. My conscience falsifies not an iota; for my knowledge I cannot answer.”
—Michel de Montaigne (1533–1592)
“No rules exist, and examples are simply life-savers answering the appeals of rules making vain attempts to exist.”
—André Breton (1896–1966)