Magnifico may refer to the following:
- Mule (Foundation)
- Robert Pešut, a Slovenian singer known also as Magnifico.
- Magnifico (film), a film from the Philippines that won the Jury Prize at the Berlin International Film Festival.
- Mr. Magnifico, a character in Kim Possible.
- Juandissimo Magnifico, a character in The Fairly OddParents.
- Walter Magnifico (born 1961), an Italian basketball player
- Italian for Magnificent