LSE may refer to:

  • London School of Economics, a school of the University of London
  • London Stock Exchange or its owner group London Stock Exchange Group
  • Lahore School of Economics, a business school in Lahore, Pakistan
  • Lahore Stock Exchange, Lahore's Stock Exchange 100 Index
  • La Crosse Municipal Airport (IATA airport code), in La Crosse, Wisconsin, United States
  • Luzern–Stans–Engelberg-Bahn, a mountain railway in Switzerland
  • LSE (programming language), a computer programming language
  • Language-Sensitive Editor, a text editor used on Digital Equipment Corporation's VMS operating system
  • Lengua de signos española, Spanish Sign Language
  • Least squares estimation
  • Libman-Sacks endocarditis, a type of nonbacterial endocarditis seen in systemic lupus erythematosus
  • Logical Sensory Extrovert, a socionics personality type
  • Luxembourg Stock Exchange