LSE may refer to:
- London School of Economics, a school of the University of London
- London Stock Exchange or its owner group London Stock Exchange Group
- Lahore School of Economics, a business school in Lahore, Pakistan
- Lahore Stock Exchange, Lahore's Stock Exchange 100 Index
- La Crosse Municipal Airport (IATA airport code), in La Crosse, Wisconsin, United States
- Luzern–Stans–Engelberg-Bahn, a mountain railway in Switzerland
- LSE (programming language), a computer programming language
- Language-Sensitive Editor, a text editor used on Digital Equipment Corporation's VMS operating system
- Lengua de signos española, Spanish Sign Language
- Least squares estimation
- Libman-Sacks endocarditis, a type of nonbacterial endocarditis seen in systemic lupus erythematosus
- Logical Sensory Extrovert, a socionics personality type
- Luxembourg Stock Exchange