LRS can refer to:
- Lactated Ringer's solution
- Learning Record Store, part of the Tin Can API
- Legislative Reference Service
- Leros Island National Airport
- Levi, Ray & Shoup, a business consulting firm
- Ley de Responsabilidad Social en Radio y Televisión, a Venezuelan broadcasting law
- Linear Recursive Sequence
- Linear Reference System
- Long Range Surveillance
- London River Services
- LRS are a band
- Likelihood ratio statistic