Lotto can refer to the following:
- Lottery, a form of gambling; lottery refers to a collection of games, while certain specific games have Lotto or Loto as (part of) the name.
- Pick 6 (lottery), a type of game that often has "Lotto" in its name
- For various lotteries and lottery games with Lotto or Loto in the name, see Category:Lotteries.
- Lotto carpet, a carpet having a lacy arabesque pattern
- Lotto Sport Italia, an Italian sports apparel manufacturer
- Lotto (cycling team), a Belgian cycling team
- Lorenzo Lotto, an Italian painter active during the Renaissance
- "Lotto" (The Office), a 2011 episode of the US television series