Biological Roles of Isopeptide Bonds: Signalling and Structural
The function of enzyme generated isopeptide bonds can be roughly divided into two separate categories; signaling and structure. In the case of the former these can be a wide range of functions, influencing protein function, chromatin condensation, or protein half-life. With regard to the latter category, isopeptides can play a role in a variety of structural aspects, from helping to form the clots in wound healing, roles in extra cellular matrix upkeep & apoptsis pathway, roles in the formation of pathogenic pilin, restructuring of the actin skeleton of a host cell to help in the pathogenecity of V. cholerae, and modifiying the properties micro-tubilin to influence its role in the structure of a cell.
The chemistries involved in the formation of these said isopeptide bonds also tend to all into these two categories. In the case of Ubiquitin and Ubiquitin like Proteins, tend to have a structured pathway of continuously passing along the peptide with a series of reactions, using multiple intermediate enzymes to reach the target protein for the conjugation reaction. The structural enzymes while varying from bacterial and eukaryotic domains, tend to be single enzymes that generally in a single step, fuse the two substrates together for a larger repetitive process of linking and inter-linking the said substrates to form and influence large macromolecular structures.
Read more about this topic: Isopeptide Bond
Famous quotes containing the words biological, roles and/or structural:
“I am fifty-two years of age. I am a bishop in the Anglican Church, and a few people might be constrained to say that I was reasonably responsible. In the land of my birth I cannot vote, whereas a young person of eighteen can vote. And why? Because he or she possesses that wonderful biological attribute—a white skin.”
—Desmond Tutu (b. 1931)
“It was always the work that was the gyroscope in my life. I don’t know who could have lived with me. As an architect you’re absolutely devoured. A woman’s cast in a lot of roles and a man isn’t. I couldn’t be an architect and be a wife and mother.”
—Eleanore Kendall Pettersen (b. 1916)
“The reader uses his eyes as well as or instead of his ears and is in every way encouraged to take a more abstract view of the language he sees. The written or printed sentence lends itself to structural analysis as the spoken does not because the reader’s eye can play back and forth over the words, giving him time to divide the sentence into visually appreciated parts and to reflect on the grammatical function.”
—J. David Bolter (b. 1951)