Innocenzo Manzetti - Family

Family

Manzetti married Rosa Sofia Anzola in 1864. His first daughter, Maria Sofia, died in 1867 at the age of two. Manzetti himself died in Aosta on his 51st birthday, poor and largely unrecognized, one year after the death of his second and last daughter, Marina Fortunata.

His brother's grand-grandson, Sergio Manzetti, much later (2001) published the "Manzetti Mechanism", that describes the hydrolysis of peptides from a group of enzymes called metalloproteases. He also published a tentative approximation of exploiting universal non-additivity with Le Chatelier's Principle for architecturing perpetual energy-generating nano-units driven by enzymes. The aspect of perpetuality is based on the continuous fluctuation of ions separated by nano-layers with pores. The pores regulate the fluctuation of ions by enzyme function of a group of enzymes called Voltage-gated potassium channels, who react to a specific change in voltage. The change in voltage is perpetuated by Le Chatelier's mechanism. Non-additive contributions to enzyme function are expected to affect in turn the entropy of the chambers, which when multiplied to many chambers, is expected to act as an independent force differing from the Le Chatelier's effects. This becomes the driving force of the nanoenergetic cell, through the arising alternating voltage-potential between chambers.