Higbee can refer to:
- People
- Lenah Higbee (1874-1941), pioneering United States Navy nurse
- Mahlon Higbee (1901-1968), an American Major league Baseball catcher
- Places
- Higbee, Missouri, a city in Randolph County, Missouri, in the United States
- Other
- Higbee's, a former Cleveland, Ohio, department store
- USS Higbee (DD-806), a United States Navy destroyer in commission from 1945 to 1979