Chemistry
Glycation of proteins is a frequent occurence, but in the case of hemoglobin, a nonenzymatic reaction occurs between glucose and the amino-terminal valine (N-terminal end) of the alpha chain. This forms a Schiff base which is itself converted to 1-deoxyfructose attached to the valine. This rearrangement is known as Amadori rearrangement.
Read more about this topic: Glycated Hemoglobin
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