Gagne or Gagné is a surname, and may refer to:
- Arsène Gagné (1910 - 1964), Canadian politician
- Éric Gagné (born 1976), Canadian baseball player
- Etienne-Paulin Gagne, French poet, writer, eccentric
- Greg Gagne (wrestler) (born 1948: family name pronounced GON-yuh)
- Greg Gagne (baseball player) (born 1961: family name pronounced GAG-nee)
- Jean Gagné, Canadian wrestler
- Marie-Pierre Gagné, Canadian synchronized swimmer
- Michel Gagné, Canadian cartoonist
- Robert M. Gagné, American educational psychologist
- Simon Gagné, Canadian hockey player
- Verne Gagne (born 1926), American wrestler and wrestling promoter; also father of wrestler Greg Gagne
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