Denise' may refer to:

  • Denise (Brazil), a municipality in Mato Grosso, Brazil
  • "Denise", a 1963 song by Randy & the Rainbows, also known as "Denis" (song), as covered by Blondie
  • Saint Denise (disambiguation)
  • Denise (computer chip), a video graphics chip from the Amiga computer
  • Denise (given name), people with the given name Denise
  • SP-350 Denise, a small submarine also known as the "Diving saucer"
  • Hurricane Denise (disambiguation)