Denise' may refer to:
- Denise (Brazil), a municipality in Mato Grosso, Brazil
- "Denise", a 1963 song by Randy & the Rainbows, also known as "Denis" (song), as covered by Blondie
- Saint Denise (disambiguation)
- Denise (computer chip), a video graphics chip from the Amiga computer
- Denise (given name), people with the given name Denise
- SP-350 Denise, a small submarine also known as the "Diving saucer"
- Hurricane Denise (disambiguation)