DDC may stand for:
- Hip-hop group Deep Dickollective, also known as D/DC
- Dewey Decimal Classification
- Digital Down Converter, one of the methods in digital signal processing
- Direct Digital Control, reading and steering of HVAC devices
- Display Data Channel, communication protocol between a graphics card and a monitor defined by VESA
- The U.S. District Court for the District of Columbia
- Detroit Diesel Corporation
- The IATA airport code for Dodge City Regional Airport in Dodge City, Kansas
- Dopa Decarboxylase or Aromatic-L-amino-acid decarboxylase
- Double Disc Court
- Dideoxycytidine (ddC)
- Dzongkha Development Commission