Chappuis /ˈtʃæpiəs/ is a surname. Notable people with the surname include:
- Robert "Bob" Richard Chappuis (1923–2012), American football player
- Eduardo Dibós Chappuis (called "Chachi"), Peruvian politician
- Eliane Cat-Tuong Chappuis (born 1978), model, actress, singer, producer of Swiss descent
- Friedrich-Wilhelm von Chappuis (1886–1942), General der Infanterie
- Jason Lamy-Chappuis (born 1986, Missoula, Montana, USA), Franco-American ski jumper and cross-country skier
- Liliane Chappuis (1955–2007), Swiss politician
- Marie de Sales Chappuis, aka Marie-Thérèse Chappuis
- Paul Emile Chappuis (1816–1887), photographer, an inventor and manufacturer
- Philippe Chappuis (born 1967)
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