Blanc or le Blanc is a surname of French origin, meaning White. Bearers of the name include the following.
- Antoine Blanc, first Archbishop of New Orleans
- Antoine le Blanc (19th century), French immigrant to the United States, celebrated murderer
- Bertrand Blanc (b. 1973), French ski mountaineer
- Charles Blanc (1813-1882), French art critic
- Didier Blanc (b. 1984), French ski mountaineer
- Emmanuel Blanc (b. 1972), French ski mountaineer
- Erika Blanc (born 1942), Italian actress
- Ernest Blanc, opera singer
- Jacques Blanc (born 1939), French politician
- Jennifer Blanc (born 1974), American actress
- Laurent Blanc (born 1965), French manager and former footballer
- Louis Blanc (1811–1882), French politician and historian
- Martine Blanc (born 1944), French children's book author and illustrator
- Mel Blanc (1908–1989), American actor
- Nathalie Blanc (b. 1967), French ski mountaineer
- Patrick Blanc (b. 1953), French botanist
- Patrick Blanc (ski mountaineer), (b. 1972), French ski mountaineer
- Raymond Blanc (born 1949), French chef
- Samuel Blanc, invented the Roto-Rooter drain-cleaning machine
- Blanc, a fictional character in the game Hyperdimension Neptunia