Big Bill may refer to:
- "Big Bill" Dwyer (1883–1946), prohibition gangster and bootlegger
- "Big Bill" Tilden (1893–1953), American tennis player
- Bill Haywood, (1869–1928), prominent figure of the American labor movement
- Bill James (1887–1942), starting pitcher in Major League Baseball
- Big Bill Bissonnette (born 1937), American jazz trombonist and producer
- Big Bill Broonzy (1898–1958), American blues singer and guitarist
- Big Bill Morganfield (born 1956), American blues singer and guitarist
- Big Bill Neidjie (circa 1920–2002), last surviving speaker of the Gagudju language
- Bill Bachrach (1879-1959), American swim and water polo coach
- Bill Werbeniuk (1947–2003), Canadian snooker player
- Big Bill Laplante (1980- present) Most epic DJ and host of Big Bill's Indie Underground. Calgary Alberta Canada.
Famous quotes containing the words big and/or bill:
“I’m headed for a land that’s far away
Beside the crystal fountains.
So come with me, we’ll go and see
The Big Rock Candy Mountains.”
—Unknown. The Big Rock Candy Mountains (l. 5–8)
“[My one tennis book] was very, very old. It had a picture of Bill Tilden. I looked at the picture and that was how I learned to hold the racket.”
—Maria Bueno (b. 1939)