Wernicke is a surname, and may refer to
- Carl Wernicke (1848–1905), German physician after which the Wernicke's area, Wernicke's aphasia, Wernicke's encephalopathy and Wernicke-Korsakoff syndrome are named
- Christian Wernicke (1671–1725), German writer
- Erich Wernicke (de) (1859–1928), German immunologist and microbiologist
- Eva-Maria Wernicke-Wehling (de) (born 1953)
- Friedrich Wernicke (de) (1902–1982)
- Herbert Wernicke (1946–2002)
- Horst Wernicke (de) (born 1951), German historian
- Horst Wernicke (novelist) (born 1935), German novelist
- Israel Gottlieb Wernicke (de) (1755–1836), Danish-Norwegian composer and pianist
- Kenneth (Ken) Wernicke, US engineer working on tilt rotor aircraft
- Konrad Wernicke (de) (1862–1900), German classical archaeologist and philologist
- Otto Wernicke (1893–1965), German actor
- Petra Wernicke (de) (born 1953), German female politician (CDU)