SAPI may stand for:
- Speech Application Programming Interface, an API produced by Microsoft for Speech Recognition and Speech Synthesis
- Server Application Programming Interface, an API used by PHP to interface with Web Servers
- Small Arms Protective Insert, a military ballistic protection system
- Systém automatického pořizování informací (system for automatic gathering of information): SAPI-1, a computer produced in former Czechoslovakia by Tesla
- Network Service Access Point Identifier, an identifier used in GPRS (cellular data) networks.
- A nickname for the name 'Sapna' found in the Hindi language. Usage has been documented in North Eastern Ohio
- SaPI, a family of pathogenicity islands found in Staphylococcus aureus