Entertainment
- Prime Mover (film), a 2009 Australian romantic crime film set in Dubbo
- An episode of The Twilight Zone, "The Prime Mover"
- Prime Mover, the 1987 hit single from Zodiac Mindwarp
- Prime Mover, the title of a song on Rush's 1987 album Hold Your Fire
- Prime Mover, the title of a 1988 album from the band Kerry Livgren
- Prime Mover, the title of a song on Ghost's 2010 album Opus Eponymous
- Prime Mover (videogame), a videogame published by Psygnosis in 1993
- The Prime Movers, a quasi-omniscient race of alien superbeings in the Buck Godot comic series by Phil Foglio
- The Prime Movers (Michigan band), a 60's band featuring a pre-Stooges Iggy Pop
- The Prime Movers (Los Angeles band), a predecessor band of Dread Zeppelin
- The Prime Movers (British band), a band founded by Graham Day of The Prisoners
- Prime Mover (comics), a fictional character in the Marvel Universe
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