PNC may refer to:
- Colombian National Police, in Spanish: Policía Nacional de Colombia
- Palestinian National Council, the legislative body of the Palestine Liberation Organization
- Partitu di a Nazione Corsa (Party of the Corsican Nation), a nationalist political party in Corsica
- People's National Congress, a socialist political party in Guyana
- Plate number coil, a postage stamp with the number of the printing plate printed on it
- PNC (rapper), a New Zealand rapper
- PNC Financial Services, a Fortune 500 company
- PNC Park, a baseball park located in Pittsburgh, Pennsylvania named for the above company
- PNC Field, a baseball park located in Moosic, Pennsylvania
- PNC Arena, a multipurpose indoor arena in Raleigh, North Carolina
- PNC Bank Arts Center, a modern amphitheatre in Holmdel Township, New Jersey
- Police National Computer in the United Kingdom
- Pritish Nandy Communications, a media company based in Mumbai, India
- Purdue University North Central, a branch of Purdue University in Westville, Indiana
- Pan Nordic Card association, an organisation for financial organisations working with payment cards in the Nordic region