O
- Jim Oberstar (born 1934) – member of U.S. Congress
- Tim O'Brien (born 1946) – author
- Mac O'Grady (born 1951) – golfer
- Michael O'Leary (born 1958) – actor
- Tim Ocel – director
- Willie Offord (born 1978) – football player
- Joseph P. O'Hara (1895–1975) – member of U.S. Congress
- Kyle Okposo (born 1988) – hockey player
- Tony Oliva § (born 1938) – baseball player
- Alec G. Olson (born 1930) – member of U.S. Congress; 40th Lieutenant Governor of Minnesota
- Earl B. Olson (1915–2006) – founder of the Jennie-O Turkey company
- Floyd B. Olson (1891–1936) – 22nd Governor of Minnesota
- Greg Olson (born 1960) – baseball player
- Howard Olson (1937–1996) – politician, farmer
- John Olson (1906–1981) – politician, farmer
- Katy Olson (born 1928) – politician, farmer
- Kenneth L. Olson (1945–1968) – Vietnam War veteran
- Mark Olson (born 1943) – member of the Board of Governors of the U.S. Federal Reserve
- Sigurd Olson (1899–1982) – environmentalist
- Norman J. Ornstein – political scientist
- Dave Osborn – football player
- T.J. Oshie § – N.H.L Player.
- Laura Osnes (born 1985) – actor, singer
- Peter Ostroushko (born 1953) – violinist
- Rebecca Otto (born 1963) – politician, 18th state auditor
- Owl City Music group
Read more about this topic: List Of People From Minnesota