Route Description
Illinois 21 was the principal route to Milwaukee, Wisconsin before the construction of both the Skokie Highway and the Tri-State Tollway (Interstate 94 and Interstate 294). The towns of Glenview, Libertyville, and Gurnee are principally located along this road. It follows the Des Plaines River for its entire length, and overlaps U.S. Route 45 between Lincolnshire and Prospect Heights.
South of Illinois 43, Milwaukee Avenue remains a major arterial road until it reaches the downtown area of Chicago, where its historical terminus at Lake Street has been moved back to Grand Avenue. It is one of the few diagonal streets in the grid street layout of Chicago.
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