EPF may stand for:
- Early pregnancy factor, one of the earliest markers of pregnancy in mammals
- Eclipse Process Framework, an open source project providing tools and frameworks for software process engineering
- Employees Provident Fund, Malaysia's mandatory saving and social security plan.
- Employees Provident Fund, India's mandatory saving and social security plan.
- Ensuring Positive Futures, an employment programme for people living with HIV in the UK
- Environmental Protection Fund, a fund setup in New York State for state environmental programs.
- European Parliamentary Forum on Population and Development, a network of MPs from across Europe who are committed to advancing reproductive health and family planning on the international development agenda
- Ex post facto law, a law that retroactively changes the legal consequences of acts committed
- Club Penguin: Elite Penguin Force, a game for Nintendo DS made by Disney.