Model Organisms
| Characteristic | Phenotype |
|---|---|
| Homozygote viability | Abnormal |
| Recessive lethal study | Normal |
| Homozygous Fertility | Abnormal |
| Body weight | Abnormal |
| Anxiety | Abnormal |
| Neurological assessment | Abnormal |
| Grip strength | Normal |
| Hot plate | Normal |
| Dysmorphology | Abnormal |
| Indirect calorimetry | Abnormal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Abnormal |
| Radiography | Abnormal |
| Body temperature | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology | Abnormal |
| Peripheral blood lymphocytes | Abnormal |
| Heart weight | Normal |
| Salmonella infection | Normal |
| Citrobacter infection | Normal |
| All tests and analysis from |
Model organisms have been used in the study of ZC3HC1 function. A conditional knockout mouse line, called Zc3hc1tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty two tests were carried out on mutant mice and eleven significant abnormalities were observed. Fewer than expected homozygous mutant mice were identified at weaning. Mutants appear to be subfertile, had decreased vertical activity in an open field, decreased lean body mass, decreased rib number and decreased mature B cell number. Males also had a decreased body weight, an abnormal posture and atypical indirect calorimetry data. Females also had an abnormally short snout and atypical haematology parameters .
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