ZC may refer to:
- Zangger Committee, a committee on nuclear proliferation
- Zettacoulomb, an SI unit of electric charge
- In set theory, the name for a system with Zermelo's first five axioms plus the axiom of choice
- In mathematics, Zadoff–Chu sequence, a certain complex-valued sequence with the CAZAC property (constant amplitude zero autocorrelation waveform)
- Honda D engine, an engine variant produced by Honda Motor Company