Gene Ontology | |
---|---|
Molecular function | • RNA binding • NAD+ ADP-ribosyltransferase activity • protein binding • zinc ion binding • metal ion binding |
Cellular component | • nucleus • cytoplasm • Golgi apparatus • plasma membrane |
Biological process | • response to virus • positive regulation of type I interferon production • positive regulation of interferon-alpha production • positive regulation of interferon-beta production • positive regulation of I-kappaB kinase/NF-kappaB cascade • negative regulation of viral genome replication • innate immune response • regulation of defense response to virus by host • defense response to virus • positive regulation of mRNA catabolic process • cellular response to exogenous dsRNA • positive regulation of RIG-I signaling pathway |
Sources: Amigo / QuickGO |
138.73 – 138.79 Mb
38.31 – 38.35 Mb
Zinc finger CCCH-type antiviral protein 1 is a protein that in humans is encoded by the ZC3HAV1 gene.
This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described.