ZC3HAV1

Identifiers Symbols ZC3HAV1; ARTD13; FLB6421; PARP13; ZAP; ZC3H2; ZC3HDC2 External IDs OMIM: 607312 MGI: 1926031 HomoloGene: 10585 GeneCards: ZC3HAV1 Gene

Gene Ontology
Molecular function RNA binding
NAD+ ADP-ribosyltransferase activity
protein binding
zinc ion binding
metal ion binding
Cellular component nucleus
cytoplasm
Golgi apparatus
plasma membrane
Biological process response to virus
positive regulation of type I interferon production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of I-kappaB kinase/NF-kappaB cascade
negative regulation of viral genome replication
innate immune response
regulation of defense response to virus by host
defense response to virus
positive regulation of mRNA catabolic process
cellular response to exogenous dsRNA
positive regulation of RIG-I signaling pathway
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 56829 78781 Ensembl ENSG00000105939 ENSMUSG00000029826 UniProt Q7Z2W4 Q3UPF5 RefSeq (mRNA) NM_020119 NM_028421 RefSeq (protein) NP_064504 NP_082697 Location (UCSC) Chr 7:
138.73 – 138.79 Mb Chr 6:
38.31 – 38.35 Mb PubMed search

Zinc finger CCCH-type antiviral protein 1 is a protein that in humans is encoded by the ZC3HAV1 gene.


This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described.