WOSU may refer to:
- WOSU Public Media, a nonprofit broadcasting organisation
- The WOSU Stations, a group of broadcasting stations administered by WOSU Public Media:
- WOSU (AM), a defunct radio station (820 AM), which belonged to The WOSU Stations, licensed to Columbus, Ohio, United States and is now WVSG (AM) airing Catholic programming.
- WOSU-FM, a radio station (89.7 FM), belonging to The WOSU Stations, licensed to Columbus, Ohio, United States
- WOSU-TV, a television station (channel 34 analog/38 digital), belonging to The WOSU Stations, licensed to Columbus, Ohio, United States
- WOSA-FM, a radio station (101.1 FM) belonging to The WOSU Stations and branded as "Classical 101FM", licensed to Grove City, Ohio, United States.
- Women's Shelter Uganda (official acronym WOSU), a civil organisation helping women against domestic violence