Wein means grape, vine, wine in German and Yiddish.
According to Nelly Weiss, Wein- style family names originated from signboards (house sign, house shield) in Jewish communities. Wein may also be related the German verb "weinen" (to cry).
Notable people with the surname Weininclude:
- Albert Wein, American sculptor
- Berel Wein, Orthodox rabbi
- Desiderius Wein (1873–1944), Hungarian doctor, gymnast
- Elizabeth E. Wein, an American author residing in Scotland
- George Wein, jazz pianist
- Glynis Wein, a colorist in the comics industry, first wife of Len Wein
- Len Wein, an American comic book writer