Vasopressin

Vasopressin

Identifiers Symbols AVP; ADH; ARVP; AVP-NPII; AVRP; VP External IDs OMIM: 192340 MGI: 88121 HomoloGene: 417 GeneCards: AVP Gene

Gene Ontology
Molecular function	• protein kinase activity • signal transducer activity • receptor binding • neuropeptide hormone activity • neurohypophyseal hormone activity • V1A vasopressin receptor binding • V1B vasopressin receptor binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Cellular component	• extracellular region • extracellular space • cytosol • secretory granule • dendrite
Biological process	• maternal aggressive behavior • positive regulation of systemic arterial blood pressure • generation of precursor metabolites and energy • protein phosphorylation • water transport • signal transduction • elevation of cytosolic calcium ion concentration • cell-cell signaling • negative regulation of female receptivity • grooming behavior • locomotory behavior • positive regulation of cell proliferation • positive regulation of gene expression • positive regulation of glutamate secretion • positive regulation of cell growth • positive regulation of cAMP biosynthetic process • positive regulation of prostaglandin biosynthetic process • positive regulation of cellular pH reduction • positive regulation of peptidyl-serine phosphorylation • response to nicotine • social behavior • regulation of renal sodium excretion • vasoconstriction • hyperosmotic salinity response • maternal behavior • negative regulation of apoptotic process • penile erection • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • sodium-independent organic anion transport • response to ethanol • positive regulation of vasoconstriction • multicellular organismal water homeostasis • negative regulation of transmission of nerve impulse • transmembrane transport • ERK1 and ERK2 cascade • protein kinase C signaling cascade • negative regulation of release of cytochrome c from mitochondria
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 551 11998 Ensembl ENSG00000101200 ENSMUSG00000037727 UniProt P01185 P35455 RefSeq (mRNA) NM_000490.4 NM_009732.1 RefSeq (protein) NP_000481.2 NP_033862.1 Location (UCSC) Chr 20:
3.06 – 3.07 Mb Chr 2:
130.58 – 130.58 Mb PubMed search

Arginine vasopressin (AVP), also known as vasopressin, argipressin or antidiuretic hormone (ADH), is a neurohypophysial hormone found in most mammals. Vasopressin is responsible for regulating the body's retention of water by acting to increase water absorption in the collecting ducts of the kidney nephron. Vasopressin increases water permeability of the kidney's collecting duct and distal convoluted tubule by inducing translocation of aquaporin-CD water channels in the kidney nephron collecting duct plasma membrane. Vasopressin is a peptide hormone that controls the reabsorption of molecules in the tubules of the kidneys by affecting the tissue's permeability. It also increases peripheral vascular resistance, which in turn increases arterial blood pressure. It plays a key role in homeostasis, by the regulation of water, glucose, and salts in the blood. It is derived from a preprohormone precursor that is synthesized in the hypothalamus and stored in vesicles at the posterior pituitary. Most of it is stored in the posterior pituitary to be released into the bloodstream. However, some AVP may also be released directly into the brain, and accumulating evidence suggests it plays an important role in social behavior, bonding, and maternal responses to stress.