Urrutia, meaning "distant, far away" in Euskera, is the name of a family that originated in Zumarraga in the province of Guipuzcoa, and then spread out throughout the Basque country, and eventually throughout the Americas – South, Central and North. Notable members of the Urrutia family include:
- Abraham Oyanedel Urrutia, Chilean politician and jurist
- Aliecer Urrutia (born 1974), Cuban athlete
- Alfonso Hortiz de Urrutia, 15th-century Spanish humanist writer
- Aureliano Urrutia (1871–1975), Mexican physician and politician
- Benjamin Urrutia, Ecuadorian-American writer
- Carlos Luis de Urrutia, 19th-century governor of Santo Domingo
- Estíbaliz Urrutia, Spanish long-distance runner
- Francisco de Paula Urrutia Ordóñez, Colombian diplomat
- Francisco José Urrutia Olano, Colombian diplomat
- Francisco José Urrutia Holguín, Colombian diplomat and jurist
- Ignacio Urrutia Manzano, Chilean politician
- Ignacio Jose Urrutia, Cuban historian
- Ilma Urrutia, Guatemalan beauty pageant contestant
- Jenaro de Urrutia Olaran, Basque painter
- Jorge Urrutia, Chilean composer
- José de Urrutia, Tejano military
- Josu Urrutia, Spaniard footballer
- Juan Antonio de Urrutia y Arana, Mexican nobleman and patron of the arts
- Manuel Urrutia Lleó, 20th President of Cuba
- María Isabel Urrutia, Colombian athlete and politician
- Matilde Urrutia, wife of Pablo Neruda
- Miguel Urrutia Montoya, Colombian economist and politician
- Osmani Urrutia Ramírez, Cuban baseball player
- Patricio Urrutia, Ecuadorian footballer
- Roberto Urrutia, Cuban American Olympic weightlifter
- Ruben Urrutia, Puerto Rican rapper
- Enrique Alvear Urrutia, Chilean bishop
- Ignacio Bolívar y Urrutia, Spaniard naturalist and entomologist
- Diego Dublé Urrutia, Chilean poet and diplomat
- José Antonio Gómez Urrutia, Chilean lawyer and politician
- Luis Gilberto Murillo Urrutia, Colombian engineer and politician
- Pedro R. Pierluisi Urruti, Puerto Rican lawyer and politician
- Iban Zubiaurre Urrutia, Spaniard footballer