Upf1

UPF1

Identifiers Symbols UPF1; HUPF1; NORF1; RENT1; pNORF1; smg-2 External IDs OMIM: 601430 MGI: 107995 HomoloGene: 2185 GeneCards: UPF1 Gene

Gene Ontology
Molecular function	• DNA binding • chromatin binding • RNA binding • ATP-dependent RNA helicase activity • helicase activity • protein binding • ATP binding • zinc ion binding
Cellular component	• chromatin • cytoplasmic mRNA processing body • nucleus • cytoplasm • cytosol • exon-exon junction complex • supraspliceosomal complex
Biological process	• nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • DNA replication • DNA repair • mRNA export from nucleus • regulation of translational termination • cell cycle • dosage compensation by inactivation of X chromosome • gene expression • RNA metabolic process • mRNA metabolic process • histone mRNA catabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5976 19704 Ensembl ENSG00000005007 ENSMUSG00000058301 UniProt Q92900 Q9EPU0 RefSeq (mRNA) NM_002911 NM_001122829 RefSeq (protein) NP_002902 NP_001116301 Location (UCSC) Chr 19:
18.94 – 18.98 Mb Chr 8:
70.33 – 70.35 Mb PubMed search

Regulator of nonsense transcripts 1 is a protein that in humans is encoded by the UPF1 gene.