U4atac minor spliceosomal RNA is a ncRNA which is an essential component of the minor U12-type spliceosome complex. The U12-type spliceosome is required for removal of the rarer class of eukaryotic introns (AT-AC, U12-type).
U4atac snRNA is proposed to form a base-paired complex with another spliceosomal RNA U6atac via two stem loop regions. These interacting stem loops have been shown to be required for in vivo splicing. U4atac also contains an 3' Sm protein binding site which has been shown to be essential for splicing activity. U4atac is the functional analog of U4 spliceosomal RNA in the major U2-type spliceosomal complex.
The Drosophila U4atac snRNA has an additional predicted 3' stem loop terminal to the Sm binding site.
Read more about U4atac Minor Spliceosomal RNA: Disease
Famous quotes containing the word minor:
“If, for instance, they have heard something from the postman, they attribute it to “a semi-official statement”; if they have fallen into conversation with a stranger at a bar, they can conscientiously describe him as “a source that has hitherto proved unimpeachable.” It is only when the journalist is reporting a whim of his own, and one to which he attaches minor importance, that he defines it as the opinion of “well-informed circles.””
—Evelyn Waugh (1903–1966)