Trinucleotide repeat disorders (also known as trinucleotide repeat expansion disorders, triplet repeat expansion disorders or codon reiteration disorders) are a set of genetic disorders caused by trinucleotide repeat expansion, a kind of mutation where trinucleotide repeats in certain genes exceed the normal, stable threshold, which differs per gene. The mutation is a subset of unstable microsatellite repeats that occur throughout all genomic sequences. If the repeat is present in a healthy gene, a dynamic mutation may increase the repeat count and result in a defective gene.
Trinucleotide repeats are sometimes classified as insertion mutations and sometimes as a separate class of mutations.
Read more about Trinucleotide Repeat Disorders: Summary, History, Symptoms, Genetics, Types, Trinucleotide Repeat Expansion
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