Trinucleotide repeat disorders (also known as trinucleotide repeat expansion disorders, triplet repeat expansion disorders or codon reiteration disorders) are a set of genetic disorders caused by trinucleotide repeat expansion, a kind of mutation where trinucleotide repeats in certain genes exceed the normal, stable threshold, which differs per gene. The mutation is a subset of unstable microsatellite repeats that occur throughout all genomic sequences. If the repeat is present in a healthy gene, a dynamic mutation may increase the repeat count and result in a defective gene.
Trinucleotide repeats are sometimes classified as insertion mutations and sometimes as a separate class of mutations.
Read more about Trinucleotide Repeat Disorders: Summary, History, Symptoms, Genetics, Types, Trinucleotide Repeat Expansion
Famous quotes containing the words repeat and/or disorders:
“Guilty, guilty, guilty is the chant divorced parents repeat in their heads. This constant reminder remains just below our consciousness. Nevertheless, its presence clouds our judgment, inhibits our actions, and interferes in our relationship with our children. Guilt is a major roadblock to building a new life for yourself and to being an effective parent.”
—Stephanie Marston (20th century)
“It no longer makes sense to speak of “feeding problems” or “sleep problems” or “negative behavior” is if they were distinct categories, but to speak of “problems of development” and to search for the meaning of feeding and sleep disturbances or behavior disorders in the developmental phase which has produced them.”
—Selma H. Fraiberg (20th century)