TRC is a three letter acronym that can refer to:
- Media and popular culture
- The Red Chord, an American music group
- Tomb Raider Chronicles, fifth title in the Tomb Raider video game series
- Tsubasa: RESERVoir CHRoNiCLE, a manga and anime made by CLAMP
- Organizations, companies
- Thomas Rotherham College
- The RNAi Consortium
- Télévision de Radio-Canada
- Tanzania Railways Corporation
- Trona Railway, which uses the reporting mark TRC
- Francisco Sarabia International Airport in Torreón, Coahuila, Mexico, which uses IATA airport code TRC
- Sports
- The Rugby Championship
- Triangle Ribbon Championship
- Other
- Technical Requirement Checklist, a checklist mainly used to verify the technical requirement for a platform in video game testing
- Thrombocyte, also known as platelet
- Tone reproduction curve in imaging, also known as tone response curve
- Green tags, tradable renewable certificates
- Terra (currency), the Trade Reference Currency
- Truth and reconciliation commission in various countries around the world
- Tuple relational calculus
- TRC, Lasonic boombox brand
- TRC or Row Cycle Time, one of computer memory timings.