The Effects of Cross and Self Fertilisation in the Vegetable Kingdom is a book on evolution in plants by Charles Darwin, first published in 1876. In this book Darwin examines the effects of cross and self fertilisation of plants and provides experimental evidence for a hypothesis stated in his famed book of 1859, Origin of Species, that "... in none can self-fertilisation go on for perpetuity" (Origin, p. 101). He reports on experiments conducted on over 60 different species of plants, where he used controlled pollinations in order to produce self-fertilised and cross-fertilised descendants. Through growth experiments of this progeny, he concluded that self-fertilised progeny performed poorer in most species and for most traits measured. Thus he showed that inbreeding may have severe detrimental effects on progeny. While this idea was accepted by many, e.g. plant and animal breeders, Darwin's book provided overwhelming experimental support for this idea. This book has remained the starting point for the study of inbreeding and is cited in scientific papers to this effect to this day.
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—William Shakespeare (1564–1616)
“There is a certain class of unbelievers who sometimes ask me such questions as, if I think that I can live on vegetable food alone; and to strike at the root of the matter at once,—for the root is faith,—I am accustomed to answer such, that I can live on board nails. If they cannot understand that, they cannot understand much that I have to say.”
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—William Shakespeare (1564–1616)