TCU is an abbreviation for:
- Tauranga City United, a New Zealand association football club
- Telecommunication Control Unit
- Texas Christian University, a private university in Fort Worth, Texas
- TCU Horned Frogs, the athletic program of the school
- Thompson/Center Ugalde, a family of wildcat cartridges for firearms based upon the .223 Remington, such as the 7mm TCU
- The Civilized Union
- TCu, towering cumulus; Cumulus congestus cloud
- Tokyo Christian University, a private university in Chiba, Japan
- Tokyo City University, a private university of technology in Japan
- Towering Cumulus, a family of clouds
- Transmission Control Unit
- Transitional Care Unit, a specialized facility in a hospital that provides intensive care medicine, but is a transition between ICU and regular care
- Transportation Communications Union
- Triangle Credit Union, a credit union in New Hampshire
- Tribunal de Contas da União, the Brazilian federal court of accounts
- Turn Construction Unit
- Tzu Chi University, in Hualien, Taiwan