T-cell Surface Glycoprotein CD3 Epsilon Chain

T-cell Surface Glycoprotein CD3 Epsilon Chain

Identifiers Symbols CD3E; T3E; TCRE External IDs OMIM: 186830 MGI: 88332 HomoloGene: 586 ChEMBL: 1975 GeneCards: CD3E Gene

Gene Ontology
Molecular function	• transmembrane signaling receptor activity • receptor signaling protein activity • SH3 domain binding • protein kinase binding • receptor signaling complex scaffold activity • T cell receptor binding • protein heterodimerization activity
Cellular component	• immunological synapse • plasma membrane • integral to plasma membrane • external side of plasma membrane • T cell receptor complex • alpha-beta T cell receptor complex
Biological process	• positive regulation of T cell anergy • protein complex assembly • cell surface receptor signaling pathway • transmembrane receptor protein tyrosine kinase signaling pathway • signal complex assembly • G-protein coupled receptor signaling pathway • response to nutrient • T cell costimulation • positive regulation of interferon-gamma production • positive regulation of interleukin-4 production • positive regulation of T cell proliferation • T cell activation • regulation of apoptotic process • negative thymic T cell selection • positive regulation of interleukin-2 biosynthetic process • negative regulation of smoothened signaling pathway • positive regulation of alpha-beta T cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • regulation of immune response • positive regulation of calcium-mediated signaling • T cell receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 916 12501 Ensembl ENSG00000198851 ENSMUSG00000032093 UniProt P07766 P22646 RefSeq (mRNA) NM_000733 NM_007648 RefSeq (protein) NP_000724 NP_031674 Location (UCSC) Chr 11:
118.18 – 118.19 Mb Chr 9:
45 – 45.01 Mb PubMed search

CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.