Historical Discoveries
In 1973, Terje Lømo and Tim Bliss first described the now widely studied phenomenon of long-term potentiation (LTP) in a publication in the Journal of Physiology. The experiment described was conducted on the synapse between the perforant path and dentate gyrus in the hippocampi of anaesthetised rabbits. They were able to show a burst of tetanic (100 Hz) stimulus on perforant path fibres led to a dramatic and long-lasting augmentation in the post-synaptic response of cells onto which these fibres synapse in the dendate gyrus. In the same year, the pair published very similar data recorded from awake rabbits. This discovery was of particular interest due to the proposed role of the hippocampus in certain forms of memory.
Read more about this topic: Synaptic Plasticity
Famous quotes containing the words historical and/or discoveries:
“What are your historical Facts; still more your biographical? Wilt thou know a Man ... by stringing-together beadrolls of what thou namest Facts?”
—Thomas Carlyle (1795–1881)
“Ah, I fancy it is just the same with most of what you call your “emancipation.” You have read yourself into a number of new ideas and opinions. You have got a sort of smattering of recent discoveries in various fields—discoveries that seem to overthrow certain principles which have hitherto been held impregnable and unassailable. But all this has only been a matter of intellect, Miss West—superficial acquisition. It has not passed into your blood.”
—Henrik Ibsen (1828–1906)