Sokoloff, a surname, may refer to:
- Alexandra Sokoloff, American novelist and screenwriter
- Eleanor Sokoloff, American pianist
- Marla Sokoloff, American actress
- Mel Lewis, born Melvin Sokoloff, American jazz musician/drummer
- Nikolai Sokoloff, Russian American conductor and violinist
- Vladimir Sokoloff, character actor
- Kenneth Sokoloff, American economic historian
- Nahum Sokolow (also written as Nahum Sokoloff), Zionist leader and journalist