Human Siglecs
| Name | Cellular distribution | Sialic acid linkage specificity | No. of C2-Ig domains | ITIM or positive residue |
|---|---|---|---|---|
| Sialoadhesin (Siglec-1) | Macrophages | α2,3>α2,6 | 16 | None |
| CD22 (Siglec-2) | B cells | α2,6 | 6 | ITIM |
| MAG (Siglec-4) | Myelin | α2,3>α2,6 | 4 | None |
| Siglec-15 | Unknown | α2,6 | 1 | Lysine |
| CD33 (Siglec-3) | Myeloid progenitors, Monocytes | α2,6>α2,3 | 1 | ITIM |
| Siglec-5 | Neutrophils, Monocytes | α2,3 | 3 | ITIM |
| Siglec-6 | Trophoblasts | α2,6 | 2 | ITIM |
| Siglec-7 | NK cells | α2,8>α2,6>α2,3 | 2 | ITIM |
| Siglec-8 | Eosinophils | α2,3>α2,6 | 2 | ITIM |
| Siglec-9 | Monocytes, Neutrophils, Dendritic cells | α2,3=α2,6 (prefers sulfated residues) | 2 | ITIM |
| Siglec-10 | B cells | α2,3=α2,6 | 4 | ITIM |
| Siglec-11 | B cells | α2,8 | 4 | ITIM |
| Siglec-12 | Macrophages | No binding | 2 | ITIM |
| Siglec-14 | Unknown | α2,6 | 2 | Arginine |
This table briefly summarises the cellular distribution of each human Siglec; the linkage specificity each has for sialic acid binding; the number of C2-Ig domains it contains; and whether it contains an ITIM or a positive residue to bind ITAM-containing adaptor proteins. The Siglecs in italics are conserved between humans and mice. References in the column headings correspond to all information displayed in that column, unless other references are shown. Siglec-12 information is referenced by only, excluding the linkage specificity.
Read more about this topic: SIGLEC
Famous quotes containing the word human:
“Women generally should be taught that the rough life men must needs lead, in order to be healthy, useful and manly men, would preclude the possibility of a great degree of physical perfection, especially in color. It is not a bad reflection to know that in all probability the human animal has endowments enough without aspiring to be the beauty of all creation as well as the ruler.”
—Caroline Nichols Churchill (1833–?)