Examples
The first step in the synthesis of azasugar 6 is a dihydroxylation reaction of the prochiral diene 1. Azasugars are pharmacologically relevant. The entire reaction sequence takes place in water as a reaction medium and protective groups were not required. Notice the chemoselectivity in the nucleophilic substitution of bromine by the hydroxyl group in step 2.
For another example of this reaction see: Kuwajima Taxol total synthesis
Read more about this topic: Sharpless Asymmetric Dihydroxylation
Famous quotes containing the word examples:
“There are many examples of women that have excelled in learning, and even in war, but this is no reason we should bring ‘em all up to Latin and Greek or else military discipline, instead of needle-work and housewifry.”
—Bernard Mandeville (1670–1733)
“In the examples that I here bring in of what I have [read], heard, done or said, I have refrained from daring to alter even the smallest and most indifferent circumstances. My conscience falsifies not an iota; for my knowledge I cannot answer.”
—Michel de Montaigne (1533–1592)
“Histories are more full of examples of the fidelity of dogs than of friends.”
—Alexander Pope (1688–1744)